In a bit of practical physiology that I never learned in public school but have since via the internet, when the body depletes its blood sugar, after it’s sucked whatever it can out of glycogen stores in the muscles, it turns to fatty acid-derived compounds called ketones, manufactured in the liver, that oxidize fat into usable forms of energy as an alternative to glucose.
Regarding neurodegeneration, including Alzheimer's disease, Parkinson's disease, multiple system atrophy and dementia with Lewy bodies: https://vitamindstopscovid.info/00-evi/#3.3.
Low levels of 25-hydroxyvitamin D are strongly correlated with most or all of these conditions. Since these conditions do not cause these low levels, and since the immune system is weakened and made more inflammatory (self destructive, indiscriminate cell killing - an immune response normally reserved for multicellular parasites such as intestinal worms, AKA helminths), and since these neurodegenerative diseases are caused by, at least in part, excessive inflammation, it is obvious (or should be obvious) that low 25-hydroxyvitamin D levels contribute strongly to the risk of most or all of these forms of dementia.
Dr. Terry Wahls came down with multiple sclerosis as she graduated from medical school and has developed a protocol including a ketogenic diet that keeps her disease in remission.
"Modified Paleolithic (Wahls) and low lectin modified Paleolithic (Wahls elimination). The Wahls diet is a modified Paleolithic diet that advocates for a moderate amount of meat, encourages 9 servings of vegetables and berries, and excludes gluten, casein, and eggs. The Wahls elimination diet adds exclusion of nightshade vegetables (peppers, tomatoes, eggplant, and potatoes), legumes, and grains for 3 months, with a gradual reintroduction of the nightshades, legumes, and gluten-free gains, 1 ingredient at a time, to assess tolerance to the reintroduced proteins."
Unless they supplement vitamin D3 in quantities well above those recommended by governments and many doctors, most people have only a fraction of the 25-hydroxyvitamin D (made in the liver from ingested or ultraviolet-light skin exposure produced vitamin D3) their immune system needs to function properly. Please see the research cited and discussed at: https://vitamindstopscovid.info/00-evi/ .
https://vitamindstopscovid.info/06-adv/ concerns helminths (intestinal worms) , lack of helminths, immune responses, and using helminthic infections (https://helminthictherapy.org) to suppress autoimmune diseases such as psoriasis, asthma and multiple sclerosis. It also concerns the Coimbra Protocol and other similar very high 25-hydroxyvitamin D protocols which successfully suppress the same, to striking degree, set of auto-immune diseases, including cluster headaches, migraine and lupus. I have never seen these two subjects discussed together. Leading vitamin D researchers seem to have no interest in helminths - I have been trying to interest them for the last few years. As far as I know, the helminth researchers do not think about vitamin D.
These protocols involve ~100 ng/mL (which is generally healthy - I have about this level) to 300+ ng/mL (elevated risk of hypercalcemia), 25-hydroxyvitamin D levels, under medical supervision, with low calcium diets, lots of water and monitoring of the blood calcium ion levels (which must be within a very narrow range) and parathyroid hormone levels (when low, indicating to the kidneys that there is sufficient calcium in the blood). They are highly successful, and not nearly well enough known - in part due to lack of randomised controlled trials, which its practitioners would probably consider unethical to perform.
The Coimbra protocol doctors explain the effectiveness of their protocol in terms of overcoming "vitamin D resistance". This is a vague theory and makes no sense, for various reasons. I do not know any proper explanation for why these protocols work, but they must work by enabling the body to reduce the genetically determined intensity of inflammatory response, in the absence of helminthic down-modulation.
One piece in the puzzle is the discovery by Chauss et al. 2021 (https://www.nature.com/articles/s41590-021-01080-3 explained at https://vitamindstopscovid.info/00-evi/#chauss) that Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients (who have such severe symptoms due to their immune system being too weak to stop the virus from reaching the lungs and which produces excessively strong, self-destructive, inflammatory responses to the resulting lung infection) fail to transition from their pro-inflammatory startup program, to their anti-inflammatory shutdown program, despite detecting the signal (high level of a complement protein) to do so. The researchers elucidated, for the first time, the precise details of the 25-hydroxyvitamin D -> calcitriol intracrine signaling system in Th1 lymphocytes, though they mistakenly called it "autocrine signaling", which is somewhat different. The successful operation of this intracrine signaling system is essential to the cell's ability to transition to the anti-inflammatory shutdown process. The researchers found that there was nothing intrinsically wrong with these cells. They found that the failure was largely or solely due to the cell not obtaining sufficient 25-hydroxyvitamin D, which it can only do via diffusion from the 25-hydroxyvitamin D circulating in the bloodstream.
Here you go ….Toxic Superfoods: How Oxalate Overload Is Making You Sick--and How to Get Better https://a.co/d/7vrfiPF
Thanks for linking to Sally K. Norton's work on oxalates. I will read this summary with great interest: https://sallyknorton.com/oxalate-science/oxalate-basics/.
Please see the research on vitamin D and the immune system, cited and discussed at: https://vitamindstopscovid.info/00-evi/.
Regarding neurodegeneration, including Alzheimer's disease, Parkinson's disease, multiple system atrophy and dementia with Lewy bodies: https://vitamindstopscovid.info/00-evi/#3.3.
Low levels of 25-hydroxyvitamin D are strongly correlated with most or all of these conditions. Since these conditions do not cause these low levels, and since the immune system is weakened and made more inflammatory (self destructive, indiscriminate cell killing - an immune response normally reserved for multicellular parasites such as intestinal worms, AKA helminths), and since these neurodegenerative diseases are caused by, at least in part, excessive inflammation, it is obvious (or should be obvious) that low 25-hydroxyvitamin D levels contribute strongly to the risk of most or all of these forms of dementia.
thanks for links. I've written a few articles about the suppression of vitamin D by the medical establishment in the past https://armageddonprose.substack.com/p/the-corporate-media-respects-the?utm_source=publication-search
Dr. Terry Wahls came down with multiple sclerosis as she graduated from medical school and has developed a protocol including a ketogenic diet that keeps her disease in remission.
In 2022, Dr Wahls https://www.ifm.org/about/profile/terry-wahls/ wrote an article https://www.sciencedirect.com/science/article/abs/pii/S1047965122000341 about this, but it is behind a paywall and not available via Sci-Hub. From the key points:
"Modified Paleolithic (Wahls) and low lectin modified Paleolithic (Wahls elimination). The Wahls diet is a modified Paleolithic diet that advocates for a moderate amount of meat, encourages 9 servings of vegetables and berries, and excludes gluten, casein, and eggs. The Wahls elimination diet adds exclusion of nightshade vegetables (peppers, tomatoes, eggplant, and potatoes), legumes, and grains for 3 months, with a gradual reintroduction of the nightshades, legumes, and gluten-free gains, 1 ingredient at a time, to assess tolerance to the reintroduced proteins."
Unless they supplement vitamin D3 in quantities well above those recommended by governments and many doctors, most people have only a fraction of the 25-hydroxyvitamin D (made in the liver from ingested or ultraviolet-light skin exposure produced vitamin D3) their immune system needs to function properly. Please see the research cited and discussed at: https://vitamindstopscovid.info/00-evi/ .
https://vitamindstopscovid.info/06-adv/ concerns helminths (intestinal worms) , lack of helminths, immune responses, and using helminthic infections (https://helminthictherapy.org) to suppress autoimmune diseases such as psoriasis, asthma and multiple sclerosis. It also concerns the Coimbra Protocol and other similar very high 25-hydroxyvitamin D protocols which successfully suppress the same, to striking degree, set of auto-immune diseases, including cluster headaches, migraine and lupus. I have never seen these two subjects discussed together. Leading vitamin D researchers seem to have no interest in helminths - I have been trying to interest them for the last few years. As far as I know, the helminth researchers do not think about vitamin D.
These protocols involve ~100 ng/mL (which is generally healthy - I have about this level) to 300+ ng/mL (elevated risk of hypercalcemia), 25-hydroxyvitamin D levels, under medical supervision, with low calcium diets, lots of water and monitoring of the blood calcium ion levels (which must be within a very narrow range) and parathyroid hormone levels (when low, indicating to the kidneys that there is sufficient calcium in the blood). They are highly successful, and not nearly well enough known - in part due to lack of randomised controlled trials, which its practitioners would probably consider unethical to perform.
The Coimbra protocol doctors explain the effectiveness of their protocol in terms of overcoming "vitamin D resistance". This is a vague theory and makes no sense, for various reasons. I do not know any proper explanation for why these protocols work, but they must work by enabling the body to reduce the genetically determined intensity of inflammatory response, in the absence of helminthic down-modulation.
One piece in the puzzle is the discovery by Chauss et al. 2021 (https://www.nature.com/articles/s41590-021-01080-3 explained at https://vitamindstopscovid.info/00-evi/#chauss) that Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients (who have such severe symptoms due to their immune system being too weak to stop the virus from reaching the lungs and which produces excessively strong, self-destructive, inflammatory responses to the resulting lung infection) fail to transition from their pro-inflammatory startup program, to their anti-inflammatory shutdown program, despite detecting the signal (high level of a complement protein) to do so. The researchers elucidated, for the first time, the precise details of the 25-hydroxyvitamin D -> calcitriol intracrine signaling system in Th1 lymphocytes, though they mistakenly called it "autocrine signaling", which is somewhat different. The successful operation of this intracrine signaling system is essential to the cell's ability to transition to the anti-inflammatory shutdown process. The researchers found that there was nothing intrinsically wrong with these cells. They found that the failure was largely or solely due to the cell not obtaining sufficient 25-hydroxyvitamin D, which it can only do via diffusion from the 25-hydroxyvitamin D circulating in the bloodstream.