The tacit refusal to correct lifestyle issues shouldn't be funded by government programs that provide outrageously expensive and unnecessary pharmaceutical interventions.
Years back I saw an ENT about a reflux issue. After a month or two on a proton pump inhibitor, and some unpleasant side effects, I read up on reflux. Turns out there were multiple easy to implement lifestyle changes available. When I mentioned those on my next (and LAST) visit, he told me that most people don't like lifestyle changes. Thanks Doc!!
Polycystic ovary syndrome (PCOS), an endocrine disorder afflicting 6–20% of women of reproductive age globally, has been linked to alterations in the gut microbiome. We previously showed that in PCOS, elevation of Bacteroides vulgatus in the gut microbiome was associated with altered bile acid metabolism. Here we show that B. vulgatus also induces a PCOS-like phenotype in female mice via an alternate mechanism independent of bile acids. We find that B. vulgatus contributes to PCOS-like symptoms through its metabolite agmatine, which is derived from arginine by arginine decarboxylase. Mechanistically, agmatine activates the farnesoid X receptor (FXR) pathway to subsequently inhibit glucagon-like peptide-1 (GLP-1) secretion by L cells, which leads to insulin resistance and ovarian dysfunction. Critically, the GLP-1 receptor agonist liraglutide and the arginine decarboxylase inhibitor difluoromethylarginine ameliorate ovarian dysfunction in a PCOS-like mouse model. These findings reveal that agmatine–FXR–GLP-1 signalling contributes to ovarian dysfunction, presenting a potential therapeutic target for PCOS management.
Now dont tell anyone but if you removed Bacteroides vulgatus or blocked agmatine using the arginine decarboxylase inhibitor difluoromethylarginine then most people would probably not need GLP1 which would blow a hole in thier patent revenue...
I understand your point, but Ivermectin and Hydroxychloroquine have "off label" uses. We shouldn't let the FDA and Big Pharma decide what is an appropriate use of a compound. If you restrict your inquiry of what to put into your body based on what the FDA approves, you're in for trouble.
The tacit refusal to correct lifestyle issues shouldn't be funded by government programs that provide outrageously expensive and unnecessary pharmaceutical interventions.
Years back I saw an ENT about a reflux issue. After a month or two on a proton pump inhibitor, and some unpleasant side effects, I read up on reflux. Turns out there were multiple easy to implement lifestyle changes available. When I mentioned those on my next (and LAST) visit, he told me that most people don't like lifestyle changes. Thanks Doc!!
https://www.nature.com/articles/s42255-024-01041-8
Abstract
Polycystic ovary syndrome (PCOS), an endocrine disorder afflicting 6–20% of women of reproductive age globally, has been linked to alterations in the gut microbiome. We previously showed that in PCOS, elevation of Bacteroides vulgatus in the gut microbiome was associated with altered bile acid metabolism. Here we show that B. vulgatus also induces a PCOS-like phenotype in female mice via an alternate mechanism independent of bile acids. We find that B. vulgatus contributes to PCOS-like symptoms through its metabolite agmatine, which is derived from arginine by arginine decarboxylase. Mechanistically, agmatine activates the farnesoid X receptor (FXR) pathway to subsequently inhibit glucagon-like peptide-1 (GLP-1) secretion by L cells, which leads to insulin resistance and ovarian dysfunction. Critically, the GLP-1 receptor agonist liraglutide and the arginine decarboxylase inhibitor difluoromethylarginine ameliorate ovarian dysfunction in a PCOS-like mouse model. These findings reveal that agmatine–FXR–GLP-1 signalling contributes to ovarian dysfunction, presenting a potential therapeutic target for PCOS management.
Now dont tell anyone but if you removed Bacteroides vulgatus or blocked agmatine using the arginine decarboxylase inhibitor difluoromethylarginine then most people would probably not need GLP1 which would blow a hole in thier patent revenue...
I understand your point, but Ivermectin and Hydroxychloroquine have "off label" uses. We shouldn't let the FDA and Big Pharma decide what is an appropriate use of a compound. If you restrict your inquiry of what to put into your body based on what the FDA approves, you're in for trouble.